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Generic Nameglyburide and metforminGLYE bure ide and met FOR minBrand NamesGlucovance.
There have been post-marketing cases of metformin-associated lactic acidosisincluding fatal casesThese cases had a subtle onset and were accompanied by nonspecific symptoms such as malaisemyalgiasabdominal painrespiratory distressor increased somnolencehoweverhypotension and resistant bradyarrhythmias have occurred with severe acidosisMetformin-associated lactic acidosis was characterized by elevated blood lactate concentrations5 mmol/Lanion gap acidosiswithout evidence of ketonuria or ketonemiaand an increases lactate:pyruvate ratiometformin plasma levels were generally5 mcg/mLMetformin decreases liver uptake of lactate increasing lactate blood levels which may increase the risk of lactic acidosisespecially in patients at risk.
Diabetes and eye problems are generally caused by high blood sugar levels over an extended period of timeTypes of eye problems.
An increased risk of liver enzyme elevations was observed in patients receiving glyburide concomitantly with bosentanTherefore concomitant administration of Glucovance and bosentan is contraindicated.
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