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Prometrium is used to cause menstrual periods in women who have not yet reached menopause but are not having periods due to a lack of progesterone in the bodyThis medicine is also used to prevent overgrowth in the lining of the uterus in postmenopausal women who are receiving estrogen hormone replacement therapy.
Increased risk of cervical cancer with OCP usehowever HPV remains as main risk factor for this cancerEvidence suggests long-term use of OCPs5 or more yearsmay be associated with increased riskIncreased risk of liver cancer with OCP userisk increases with longer duration of OCP use.
Using progesterone can increase your risk of blood clotsstrokeheart attackor breast cancer.
The following additional adverse experiences have been observed in women taking progestins in generalbreakthrough bleedingspottingchange in menstrual flowamenorrheachanges in weightincrease or decreasechanges in the cervical squamo-columnar junction and cervical secretionscholestatic jaundiceanaphylactoid reactions and anaphylaxisrashallergicwith and without pruritusmelasma or chloasmapyrexiaand insomnia.
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