Colchicine-mediated effects on tumor development and survival are indicative of reduced tumor cell implantation, not altered proliferation or cytotoxicity.
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If you are taking colchicine to prevent gout attackscall your doctor right away if you experience a gout attack during your treatmentYour doctor may tell you to take an extra dose of colchicinefollowed by a smaller dose one hour laterIf you take extra doses of colchicine to treat a gout attackyou should not take your next scheduled dose of colchicine until at least 12 hours have passed since you took the extra doses.
This medication may be prescribed for other usesAsk your doctor or pharmacist for more information.
Published studies demonstrated that colchicine was negative for mutagenicity in the bacterial reverse mutation assayHoweverin vitro chromosomal aberration assays demonstrated the formation of micronuclei following colchicine treatmentBecause published studies demonstrated that colchicine induces aneuploidy through the process of mitotic nondisjunction without structural DNA changescolchicine is not considered clastogenicalthough micronuclei are formed.
Rhabdomyolysismuscle damageThis serious syndrome can cause kidney diseaseand can be life-threateningSymptoms can includemuscle weakness muscle pain.
Dose reduction or alternatives should be considered for the prophylaxis of gout flares in patients with severe hepatic impairment.
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