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Other doses of oral conjugated estrogens with medroxyprogesterone acetateand other combinations and dosage forms of estrogens and progestins were not studied in the WHI clinical trials andin the absence of comparable datathese risks should be assumed to be similarBecause of these risksestrogens with or without progestins should be prescribed at the lowest effective doses and for the shortest duration consistent with treatment goals and risks for the individual woman.
Estrogens may be poorly metabolized in patients with impaired liver functionFor patients with a history of cholestatic jaundice associated with past estrogen use or with pregnancycaution should be exercised and in the case of recurrencemedication should be discontinued.
Postmarketing reportsDrug ineffectivenessblood estrogen increasefatigueexacerbation of hereditary angioedemaRef]
Please see full Prescribing InformationincludingBoxed Warning and Patient Information.
Estrace tablets 2 mgcontain FD&C Yellow No5tartrazinewhich may cause allergic-type reactionsincluding bronchial asthmain certain susceptible individualsAlthough the overall incidence of FD&C Yellow No5tartrazinesensitivity in the general population is lowit is frequently seen in patients who also have aspirin hypersensitivity.
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